Key result
The highest decile of systolic blood pressure variability was associated with an increased risk of incident dementia compared with the lowest decile (HR 1.77; 95% CI 1.17-2.69).
Why the study?
Does blood pressure variability increase the risk of incident dementia in elderly individuals?
Cohort (n=6,506)
Yes
Does blood pressure variability increase the risk of incident dementia in elderly individuals?
Hazard Ratio: 1.77 (95% CI 1.17–2.69)
p-value: p=<.02
Higher variability of systolic blood pressure over time is associated with an increased risk of incident dementia in the elderly, independent of mean blood pressure.
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Higher systolic BP variability was associated with dementia risk; hypothesis-generating for interventional trials.
Alpérovitch et al. (2013) conducted a cohort in dementia (n=6,506). High blood pressure variability (highest decile of coefficient of variation) vs. Lowest decile of blood pressure variability was evaluated on incident dementia (HR 1.77, 95% CI 1.17-2.69, p=<.02). The highest decile of systolic blood pressure variability was associated with an increased risk of incident dementia compared with the lowest decile (HR 1.77; 95% CI 1.17-2.69).
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