Implantable cardioverter defibrillator insertion plus medical therapy significantly reduced sudden cardiac death compared to medical therapy alone (1.7% vs. 11.7%; p=0.02).
Cohort (n=120)
No
Does implantable cardioverter defibrillator insertion reduce sudden cardiac death and improve overall survival in patients with nonischemic dilated cardiomyopathy?
In patients with nonischemic dilated cardiomyopathy, the addition of an ICD to standard medical therapy significantly reduces sudden cardiac death but does not significantly improve overall survival.
Absolute Event Rate: 1.7% vs 11.7%
p-value: p=0.02
BACKGROUND: Patients with nonischemic dilated cardiomyopathy (DCM) are susceptible to arrhythmias and implantable cardioverter defibrillator (ICD) in addition to medical treatments may help prevent sudden cardiac death (SCD) and improve survival in this population. HYPOTHESIS: We aim to investigate the impact of ICD insertion on survival and prognosis of patients with nonischemic DCM. METHODS: We retrospectively analyzed data from patients with nonischemic DCM treated with medical therapy with or without ICD who referred to our hospital from January 2020 to November 2021. Patients were divided based on the treatment that they had received into two equal groups. Different variables including demographic features, comorbidities, medical treatments, hospitalization rate, function class, and left ventricular ejection fraction before and after treatments were investigated in this study. In addition, variables in survival including overall survival (OS) and SCD were compared between the two groups. RESULTS: A total of 120 patients were investigated in this study. Mean ± SD of age and follow-up time of patients were 64.0 ± 12.7 years old and 61.2 ± 15.9 months, respectively. Ten (16.7%) patients with medical therapy, and seven (11.7%) patients with ICD and medical therapy died during the follow-up period (p = 0.25). However, the two groups had a significant difference regarding SCD (11.7% vs. 1.7%, p = 0.02). CONCLUSION: In patients with nonischemic DCM who had undergone ICD insertion in addition to standard medical treatments, SCD was significantly reduced compared with patients receiving just medical treatments. OS had no significant difference between our two studied groups.
Omran et al. (Fri,) conducted a cohort in Nonischemic dilated cardiomyopathy (DCM) (n=120). Implantable cardioverter defibrillator (ICD) plus medical therapy vs. Medical therapy alone was evaluated on Sudden cardiac death (SCD) (p=0.02). Implantable cardioverter defibrillator insertion plus medical therapy significantly reduced sudden cardiac death compared to medical therapy alone (1.7% vs. 11.7%; p=0.02).
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