Key result
ICD insertion linked to ~85% lower sudden cardiac death in nonischemic dilated cardiomyopathy.
Why the study?
Patients with nonischemic dilated cardiomyopathy are susceptible to arrhythmias, and whether an ICD in addition to medical treatments improves survival and prevents sudden cardiac death needed investigation.
Does implantable cardioverter defibrillator insertion reduce sudden cardiac death and improve overall survival in patients with nonischemic dilated cardiomyopathy?
Cohort (n=120)
No
Does implantable cardioverter defibrillator insertion reduce sudden cardiac death and improve overall survival in patients with nonischemic dilated cardiomyopathy?
ICD implantation in nonischemic DCM patients on optimal medical therapy reduces sudden cardiac death but may not significantly improve overall survival.
Answers are grounded in this paper and cite their sources.
ICD insertion was associated with lower sudden death but not survival in nonischemic DCM; leaves open need for randomized confirmation before practice change.
BACKGROUND: Patients with nonischemic dilated cardiomyopathy (DCM) are susceptible to arrhythmias and implantable cardioverter defibrillator (ICD) in addition to medical treatments may help prevent sudden cardiac death (SCD) and improve survival in this population. HYPOTHESIS: We aim to investigate the impact of ICD insertion on survival and prognosis of patients with nonischemic DCM. METHODS: We retrospectively analyzed data from patients with nonischemic DCM treated with medical therapy with or without ICD who referred to our hospital from January 2020 to November 2021. Patients were divided based on the treatment that they had received into two equal groups. Different variables including demographic features, comorbidities, medical treatments, hospitalization rate, function class, and left ventricular ejection fraction before and after treatments were investigated in this study. In addition, variables in survival including overall survival (OS) and SCD were compared between the two groups. RESULTS: A total of 120 patients were investigated in this study. Mean ± SD of age and follow-up time of patients were 64.0 ± 12.7 years old and 61.2 ± 15.9 months, respectively. Ten (16.7%) patients with medical therapy, and seven (11.7%) patients with ICD and medical therapy died during the follow-up period (p = 0.25). However, the two groups had a significant difference regarding SCD (11.7% vs. 1.7%, p = 0.02). CONCLUSION: In patients with nonischemic DCM who had undergone ICD insertion in addition to standard medical treatments, SCD was significantly reduced compared with patients receiving just medical treatments. OS had no significant difference between our two studied groups.
No takes yet. Share an insight, caveat, or question.
Omran et al. (2023) conducted a cohort in Nonischemic dilated cardiomyopathy (DCM) (n=120). Implantable cardioverter defibrillator (ICD) vs. Standard medical treatment only was evaluated on Sudden cardiac death (SCD) (p=0.02). Implantable cardioverter defibrillator insertion significantly reduced sudden cardiac death compared to standard medical therapy alone (1.7% vs 11.7%, p=0.02) in patients with nonischemic dilated cardiomyopathy.
Synapse has enriched 10 related papers. Consider them for comparative context: