Myocardial strain analysis using 7-T MRI detected significant decreases in longitudinal strain (two-chamber view -9.7% at 3 days and -13.9% at 9 days) after myocardial infarction in a rat model.
Does myocardial strain analysis with cardiac cine MRI detect longitudinal changes in cardiac function in a rat myocardial infarction model?
Myocardial strain analysis using 7-T cardiac cine MRI is useful for assessing longitudinal changes in myocardial function in a rat model of myocardial infarction.
This study validates the usefulness of myocardial strain analysis with cardiac cine magnetic resonance imaging (MRI) by evaluating the changes in the cardiac function and myocardial strain values longitudinally in a myocardial disease model. Six eight-week-old male Wistar rats were used as a model of myocardial infarction (MI). Cine images were taken in the short axis, two-chamber view longitudinal axis, and four-chamber view longitudinal axis directions in rats 3 and 9 days after MI and in control rats, with preclinical 7-T MRI. The control images and the images on days 3 and 9 were evaluated by measuring the ventricular ejection fraction (EF) and the strain values in the circumferential (CS), radial (RS), and longitudinal directions (LS). The CS decreased significantly 3 days after MI, but there was no difference between the images on days 3 and 9. The two-chamber view LS was -9.7 ± 2.1% at 3 days and -13.9 ± 1.4% at 9 days after MI. The four-chamber view LS was -9.9 ± 1.5% at 3 days and -11.9 ± 1.3% at 9 days after MI. Both the two- and four-chamber LS values were significantly decreased 3 days after MI. Myocardial strain analysis is, therefore, useful for assessing the pathophysiology of MI.
Onishi et al. (Tue,) conducted a other in Myocardial Infarction (n=6). Myocardial strain analysis with cardiac cine MRI vs. Control rats was evaluated on Ventricular ejection fraction and strain values in circumferential, radial, and longitudinal directions. Myocardial strain analysis using 7-T MRI detected significant decreases in longitudinal strain (two-chamber view -9.7% at 3 days and -13.9% at 9 days) after myocardial infarction in a rat model.