Does ROS scavenger (NAC) supplementation or MPO inhibition reverse endothelial dysfunction in chronic anemia?
Chronic anemia leads to endothelial dysfunction via inflammation and ROS production, suggesting that NAC or MPO inhibition may be potential therapeutic options.
Chronic anemia is associated with progressive endothelial dysfunction evidenced by activation of the endothelium mediated by systemic inflammation, increased iNOS activity, and ROS production in the arterial wall. ROS scavenger (NAC) supplementation or MPO inhibition are potential therapeutic options to reverse the devastating endothelial dysfunction in chronic anemia.
Chennupati et al. (Wed,) studied this question.