Does EAT-derived miR-92a-3p improve the myocardial redox state in the human heart?
Human epicardial adipose tissue (EAT) and myocardium
EAT-derived miR-92a-3p
Myocardial redox state and suppression of the wingless-type MMTV integration site family, member 5a/Rac1/NADPH oxidase axissurrogate
EAT-derived miR-92a-3p improves the myocardial redox state via the Wnt5a/Rac1/NADPH oxidase axis, representing a potential therapeutic target for obesity-related heart disease.
EAT-derived miRNAs exert paracrine effects on the human heart. Indeed miR-92a-3p suppresses the wingless-type MMTV integration site family, member 5a/Rac1/NADPH oxidase axis and improves the myocardial redox state. EAT-derived miR-92a-3p is related to improved clinical outcomes and is a rational therapeutic target for the prevention and treatment of obesity-related heart disease.
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Maria Cristina Carena
General / Preventive / Lipids
Ileana Badi
University of Insubria
Murray Polkinghorne
University of Oxford
Journal of the American College of Cardiology
University of Oxford
United Arab Emirates University
Oxford University Hospitals NHS Trust
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Carena et al. (Sat,) studied this question.
synapsesocial.com/papers/69d763b4ecaf04fa2648f3a9 — DOI: https://doi.org/10.1016/j.jacc.2023.05.031