Compared with vasovagal syncope, patients with situational syncope had a similar rate of positive head-up tilt test (71.1% vs 70.9%, p=0.9) but a higher prevalence of hypotensive responses.
Observational (n=1,285)
Do clinical characteristics and head-up tilt test (HUTT) responses differ between patients with situational syncope and vasovagal syncope?
Patients with situational syncope have a higher prevalence of hypotensive drug use and exhibit more hypotensive responses during head-up tilt testing compared to those with vasovagal syncope.
Absolute Event Rate: 71.1% vs 70.9%
p-value: p=0.9
OBJECTIVE: The study compared clinical characteristics and response at head-up tilt test (HUTT) between situational (SS) and vasovagal syncope (VVS). METHODS: Consecutive patients who underwent nitroglycerin-potentiated HUTT were retrospectively dichotomised into two groups: those with a history of SS and those with a history of VVS. The patients with SS were further subdivided into patients with SS alone and with SS and at least one episode of VVS. RESULTS: 1285 patients were enrolled: 246 (19.1%) had SS (SS alone in 121 and SS+VVS in 125). Patients with SS were older (48.8±20.0 vs 44.4±19.1, p=0.007) and more frequently male (57.3% vs 47.7%, p=0.001). At multivariable analysis, smoking habit (OR 2.28; p<0.0001), history of traumatic syncope (OR 2.29; p=0.0001) and ACE inhibitors/angiotensin II receptor blockers (OR 4.74; p<0.0001) were independently associated with SS. HUTT was positive in 175 (71.1%) patients with SS and in 737 (70.9%) patients with VVS (p=0.9). Patients with SS showed more mixed (42.3% vs 32.0%, p=0.002) and vasodepressor forms (10.6% vs 6.1%, p=0.01) and less cardioinhibitory responses compared with others (18.3% vs 32.8%, p<0.0001). CONCLUSIONS: Compared with VVS, patients with SS have different clinical characteristics and a higher prevalence of hypotensive drugs leading to hypotensive susceptibility. The positivity rate of HUTT is high and similar to that of VVS, although patients with SS show a higher prevalence of hypotensive responses.
Russo et al. (Tue,) conducted a observational in Situational syncope and vasovagal syncope (n=1,285). Situational syncope vs. Vasovagal syncope was evaluated on Positive response at head-up tilt test (p=0.9). Compared with vasovagal syncope, patients with situational syncope had a similar rate of positive head-up tilt test (71.1% vs 70.9%, p=0.9) but a higher prevalence of hypotensive responses.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: