Coronary artery bypass grafting significantly improved stress myocardial blood flow and flow reserve in both revascularized and non-revascularized myocardial segments, with a greater increase observed in the revascularized segments.
Observational (n=7)
Single-blind
No
Does incomplete revascularization compared to complete revascularization by CABG improve myocardial blood flow and flow reserve in patients with multivessel coronary artery disease?
Stress myocardial blood flow and flow reserve significantly improve after CABG in both revascularized and non-revascularized segments, suggesting incomplete revascularization may be a viable strategy for patients at high surgical risk.
Absolute Event Rate: 1.82% vs 1.44%
p-value: p=0.005
Abstract Purpose to prospectively compare changes in myocardial blood flow (MBF) and myocardial flow reserve (MFR) in multivessel coronary artery disease (MVCAD) patients undergoing incomplete revascularization (IR) versus complete revascularization (CR) by coronary artery bypass grafting (CABG). Methods Seven male patients (age 68 ± 9 years) with MVCAD, underwent myocardial perfusion PET/CT with 13Nammonia before and at least 4 months after CABG. Segmental resting and stress MBF as well as MFR were measured. Resting and during stress left ventricle ejection fraction (LVEF) were also calculated. Results Three patients (43%) underwent CR and 4 (57%) IR. Among 119 myocardial segments, 101 (85%) were revascularized, and 18 (15%) were not. After CABG, stress MBF (mL/min/gr) and MFR significantly increased in all myocardial segments, with a greater increase in the revascularized segments (p = 0.013). In both groups, LVEF significantly decreased during stress at baseline PET (p = 0.04), but not after CABG. Conclusion Stress MBF and MFR significantly improve after CABG in both revascularized and not directly revascularized myocardial segments. IR strategy may be considered in patients with high surgical risk for CR.
Grandinetti et al. (Thu,) conducted a observational in Multivessel coronary artery disease (n=7). Coronary artery bypass grafting (CABG) vs. Not revascularized myocardial segments was evaluated on Myocardial flow reserve (MFR) at follow-up (p=0.005). Coronary artery bypass grafting significantly improved stress myocardial blood flow and flow reserve in both revascularized and non-revascularized myocardial segments, with a greater increase observed in the revascularized segments.
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