Participants in the highest tertile of TyG-BMI had a significantly higher likelihood of heart failure compared to those in the lowest tertile (OR 2.645).
Cross-Sectional (n=7,472)
Is a high triglyceride glucose-body mass index associated with an increased prevalence of heart failure in patients with diabetes mellitus or prediabetes mellitus?
A high triglyceride glucose-body mass index is significantly associated with an increased prevalence of heart failure in individuals with diabetes or prediabetes, suggesting its potential utility as a risk marker.
Odds Ratio: 2.645 (95% CI 1.529–4.576)
p-value: p=<0.001
Background: The triglyceride glucose-body mass index (TyG-BMI) is a surrogate indicator of insulin resistance. However, the association of TyG-BMI with heart failure (HF) in individuals with diabetes mellitus or prediabetes mellitus is unknown. Methods: This study included 7,472 participants aged 20-80 years old with prediabetes or diabetes from the National Health and Nutrition Examination Survey (2007-2018). The TyG-BMI was calculated as Ln triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2 × BMI, and individuals were categorized into tertiles based on TyG-BMI levels. The relationship of TyG-BMI with HF was analyzed using multiple logistic regression models. Subgroup analyses were stratified by gender, age, hypertension, and diabetes mellitus status. Results: This cross-sectional study had 7,472 participants (weighted n = 111,808,357), including 329 HF participants. Participants with a high TyG-BMI were prone to HF. The highest tertile group with a fully adjusted model was more likely to have HF compared to the lowest tertile group (odds ratio OR, 2.645; 95% CI, 1.529-4.576). Restricted cubic spline analysis showed a significant dose-response relationship between TyG-BMI and HF (P < 0.001). In subgroup analyses, similar results were seen in terms of age (≥50 years old), gender, hypertension, and diabetes mellitus status. Conclusion: A high TyG-BMI is significantly associated with HF risk in participants with diabetes mellitus or prediabetes mellitus.
Shuping et al. (Fri,) conducted a cross-sectional in Diabetes mellitus or prediabetes mellitus (n=7,472). High triglyceride glucose-body mass index (TyG-BMI) vs. Low TyG-BMI (lowest tertile) was evaluated on Heart failure (OR 2.645, 95% CI 1.529-4.576, p=<0.001). Participants in the highest tertile of TyG-BMI had a significantly higher likelihood of heart failure compared to those in the lowest tertile (OR 2.645).