Persistently elevated galectin-3 serum levels at 6 months post-LAAO were associated with relevant peri-device leakage (17.5 ± 4.5 ng/mL) compared to completely or mostly thrombosed devices (p<0.01).
Observational (n=47)
Does galectin-3 serum level predict peri-device leakage after percutaneous left atrial appendage occlusion?
Persistently elevated galectin-3 serum levels at 6 months after LAAO are associated with relevant peri-device leakage, suggesting its potential as a biomarker for occlusion success.
p-value: p=< 0.01
Echocardiographic detection of residual peri-device leakage (PDL) after percutaneous left atrial appendage occlusion (LAAO) is crucial for managing anticoagulation. Galectin-3, a protein involved in tissue–foreign body interactions, may hold significance in understanding PDL and cardiac tissue remodeling after LAAO. This study aimed to analyze galectin-3 serum levels in relation to PDL using a novel echo-morphological classification. LAAO eligible patients were included in the study. Galectin-3 serum levels were measured before LAAO, at 45 days (45D), and at 6 months (6M) after the procedure. Transesophageal echocardiography was used to assess LAAO success. A new echo-morphological classification categorized the degree of LAAO into three different types (A: homogenous echodensity, indicating completely thrombosed device; B: inhomogeneous echolucencies ( 50%). Among 47 patients, complete LAAO was achieved in 60% after 45D and in 74% after 6M. We observed a significant increase and distribution of serum levels of galectin-3 ng/mL after 45D among the three types (baseline: 13.1 ± 5.8 ng/mL; 45D: 16.3 ± 7.2 ng/mL (Type A) vs. 19.2 ± 8.6 ng/mL (Type B) vs. 25.8 ± 9.4 ng/mL (Type C); p = 0.031), followed by a drop in galectin-3 for Types A and B after 6M toward and below the baseline levels (6M: 8.9 ± 3.1 ng/mL (Type A) vs. 12.4 ± 5.5 ng/mL (Type B)), whereas Type C persisted in showing elevated galectin-3 levels compared to all other types (6M: 17.5 ± 4.5 ng/mL (Type C); p < 0.01). Increased galectin-3 serum levels after LAAO likely reflect the transition from thrombus formation to fibrotic scar development in the LAA lumen. Successful occlusion is associated with a time-restricted decrease in galectin-3 levels after 6 months, while relevant PDL leads to persistently elevated levels, making galectin-3 a potential predictor of occlusion success.
Haertel et al. (Mon,) conducted a observational in Patients undergoing left atrial appendage occlusion (n=47). Left atrial appendage occlusion (LAAO) was evaluated on Galectin-3 serum levels across echo-morphological types of LAAO at 6 months (p=< 0.01). Persistently elevated galectin-3 serum levels at 6 months post-LAAO were associated with relevant peri-device leakage (17.5 ± 4.5 ng/mL) compared to completely or mostly thrombosed devices (p<0.01).
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