Continuous accelerated pacing in heart failure with preserved ejection fraction was associated with reduced LV wall thickness, slight LV dilation, and a small reduction in ejection fraction.
RCT
Does accelerated personalized pacing averaging 75 bpm affect cardiac structure and function in patients with heart failure with preserved ejection fraction?
Continuous accelerated pacing in HFpEF patients leads to structural changes including reduced LV wall thickness, slight LV dilation, and a small reduction in ejection fraction, without affecting diastolic function.
p-value: p=<0.001
BACKGROUND: Heart failure with preserved ejection fraction ≥50% is prevalent with few evidence-based therapies. In a trial of patients with heart failure with preserved ejection fraction with specialized pacemakers, treatment with accelerated personalized pacing averaging 75 bpm (myPACE) markedly improved quality of life, NT-proBNP (N-terminal pro-brain natriuretic peptide), physical activity, and atrial fibrillation burden compared with the standard lower rate setting of 60 bpm (usual care). METHODS AND RESULTS: <0.001). Markers of diastolic function and LV performance were not affected. CONCLUSIONS: Exposure to continuous accelerated pacing in heart failure with preserved ejection fraction is associated with a reduced LV wall thickness and a small amount of LV dilation with small reduction in ejection fraction.
Wahlberg et al. (Fri,) conducted a rct in Heart failure with preserved ejection fraction. Accelerated personalized pacing (myPACE) vs. Standard lower rate setting of 60 bpm (usual care) was evaluated on Cardiac structure and function (LV wall thickness, LV dilation, ejection fraction) (p=<0.001). Continuous accelerated pacing in heart failure with preserved ejection fraction was associated with reduced LV wall thickness, slight LV dilation, and a small reduction in ejection fraction.
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