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CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression. The development of human diseases involves important regulatory roles of RNAs, and expression profiling data can reflect the underlying etiology of inherited diseases. Hence, collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases. CHDTEPDB stores the expression profiles of over 200 sets of 7 types of CHD and provides users with more convenient basic analytical functions. Due to the differences in clinical indicators such as disease type and unavoidable detection errors among various datasets, users are able to customize their selection of corresponding data for personalized analysis. Moreover, we provide a submission page for researchers to submit their own data so that increasing expression profiles as well as some other histological data could be supplemented to the database. CHDTEPDB is a user-friendly interface that allows users to quickly browse, retrieve, download, and analyze their target samples. CHDTEPDB will significantly improve the current knowledge of expression profiling data in CHD and has the potential to be exploited as an important tool for future research on the disease.
Song et al. (Sun,) studied this question.
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