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Abstract Background Previous studies have demonstrated that delayed 68 GaGa-PSMA PET/CT imaging improves lesion detection compared to early 68 GaGa-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed 68 GaGa-PSMA PET/CT has been limited due to the insufficient number of photons obtained with standard PET/CT scanners. The combination of early and delayed 68 GaGa-PSMA standard PET/CT may be considered, and it is challenging to incorporate into a high-demand clinical setting. Long field-of-view (LFOV) PET/CT scanners have higher sensitivity compared to standard PET/CT. However, it remains unknown whether the image quality of solitary delayed 68 GaGa-PSMA LFOV PET/CT imaging is adequate to satisfy clinical diagnostic requirements. Therefore, the purpose of this study was to evaluate the image quality of delayed 68 GaGa-PSMA LFOV PET/CT and examine the feasibility of utilizing delayed 68 GaGa-PSMA LFOV PET/CT imaging alone in patients with prostate cancer. Methods The study sample consisted of 56 prostate cancer patients who underwent 68 GaGa-PSMA-11 LFOV PET/CT scanning between December 2020 and July 2021. All patients were subjected to early LFOV PET/CT imaging at 1-h post-injection as well as delayed LFOV PET/CT imaging at 3-h post-injection using 68 GaGa-PSMA-11. The image quality and diagnostic efficiency of solitary delayed 68 GaGa-PSMA-11 LFOV PET/CT imaging was analyzed. Results The results showed that delayed 68 GaGa-PSMA-11 LFOV PET/CT yielded satisfactory image quality that fulfilled clinical diagnostic benchmarks. Compared to early imaging, delayed 68 GaGa-PSMA-11 LFOV PET/CT demonstrated heightened lesion SUVmax values (11.0 2.3–193.6 vs. 7.0 2.0–124.3, P < 0.001) and superior tumor-to-background ratios (3.3 0.5–62.2 vs. 1.7 0.3–30.7, P < 0.001). Additionally, delayed 68 GaGa-PSMA-11 LFOV PET/CT detected supplementary lesions in 14 patients (25%) compared to early imaging, resulting in modifications to disease staging and management plans. Conclusions In summary, the findings indicate that the image quality of delayed 68 GaGa-PSMA-11 LFOV PET/CT is satisfactory for meeting clinical diagnostic prerequisites. The use of solitary delayed 68 GaGa-PSMA-11 LFOV PET/CT imaging in prostate cancer simplifies the examination protocol and improves patient compliance, compared to 68 GaGa-PSMA-11 standard PET/CT which necessitates both early and delayed imaging.
Yu et al. (Tue,) studied this question.