In 28 patients with celiac cardiomyopathy, treatment with a gluten-free diet and guideline-directed medical therapy resulted in cardiovascular improvement in 60.7% at 11-month follow-up.
Systematic Review (n=28)
Does a gluten-free diet combined with guideline-directed medical therapy improve cardiovascular outcomes in patients with celiac cardiomyopathy?
Celiac cardiomyopathy is a rare but potentially life-threatening condition where a combination of a gluten-free diet and guideline-directed medical therapy can lead to cardiovascular improvement in the majority of patients.
(1) Background: Cardiomyopathy in celiac disease or celiac cardiomyopathy (CCM) is a serious and potentially life-threatening disease that can occur in both adults and children. However, data supporting the causal relationship between celiac disease (CD) and cardiomyopathy (CMP) are still inconsistent. The aim of this study was to review and synthesize data from the literature on this topic and potentially reveal a more evidence-based causal relationship. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to search Medline, Embase, and Scopus databases from database inception until September 2023. A total of 1187 original articles were identified. (3) Results: We identified 28 CCM patients (19 adult and 9 pediatric) with a mean age of 27.4 ± 18.01 years. Adult patients with CCM were predominantly male (84.2%) while pediatric patients were predominantly female (75%). The most common comorbidities associated with CCM were anemia (75%) and pulmonary hemosiderosis (20%). In 35% of patients, CCM occurred before the diagnosis of CD, while in 48% of patients, CCM and CD were diagnosed at the same time. Diagnosis of CD preceded diagnosis of CCM in only 18% of patients. Diagnosis of CCM is often delayed with an average, from the onset of symptoms to diagnosis, of 16 months. All patients were treated with a gluten-free diet in addition to guideline-directed medical therapy. At 11-month follow-up, cardiovascular improvement was seen in 60.7% of patients. Pediatric mortality was 33.3%, while adult mortality was 5.3%. (4) Conclusions: Clinicians should be aware of the possible association between CD and CMP, and we recommend CD work-up in all patients with CMP who have concomitant anemia. While we identified only 28 cases in the literature, many cases might go unreported due to a lack of awareness regarding CCM. A high degree of clinical suspicion and a prompt diagnosis of CCM are essential to minimizing the risks of morbidity and mortality, as the combination of a gluten-free diet and guideline-directed medical therapy can improve clinical outcomes.
Milutinovic et al. (Mon,) conducted a systematic review in Celiac cardiomyopathy (n=28). Gluten-free diet and guideline-directed medical therapy was evaluated on Cardiovascular improvement. In 28 patients with celiac cardiomyopathy, treatment with a gluten-free diet and guideline-directed medical therapy resulted in cardiovascular improvement in 60.7% at 11-month follow-up.