February 23, 2024Open Access

Structural and Dynamic Analyses of Pathogenic Variants in PIK3R1 Reveal a Shared Mechanism Associated among Cancer, Undergrowth, and Overgrowth Syndromes

NDNikita R. DsouzaMedical College of Wisconsin CCCatherine E. CottrellNationwide Children's Hospital ODOlivia M. T. DaviesBrigham and Women's Hospital

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Abstract

The PI3K enzymes modify phospholipids to regulate cell growth and differentiation. Somatic variants in PI3K are recurrent in cancer and drive a proliferative phenotype. Somatic mosaicism of

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Dsouza et al. (Fri,) studied this question.

synapsesocial.com/papers/68e77de8b6db6435876f17ec https://doi.org/https://doi.org/10.3390/life14030297

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