FIGURE 3 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy

Key Points

• Cytokine expression in CD4 cells differs significantly at baseline, showing higher levels in complete responders.
• Complete responders exhibit notably higher CD4 effector cytokine expression compared to non-responders.
• Exploratory analysis across immune checkpoint blockade therapy settings focuses on CD4 and CD8 T-cell profiles in acute myeloid leukemia patients.  No significant variation in functional group expression from CD8 cells exists between complete responders and non-responders.