⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

March 6, 2024Open Access

FIGURE 3 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy

Jessica L. Root Poonam N. Desai Christopher Ly Bofei Wang Fatima Zahra Jelloul Jing Zhou Sean Mackay Mansour Alfayez Jairo Matthews Sherry Pierce Patrick K. Reville Naval Daver Hussein A. Abbas

View Full Paper

Ask AI

Bookmark

Share

Key Points

Cytokine expression in CD4 cells differs significantly at baseline, showing higher levels in complete responders.
Complete responders exhibit notably higher CD4 effector cytokine expression compared to non-responders.
Exploratory analysis across immune checkpoint blockade therapy settings focuses on CD4 and CD8 T-cell profiles in acute myeloid leukemia patients. No significant variation in functional group expression from CD8 cells exists between complete responders and non-responders.

Implication

Exploratory analysis reveals differences in cytokine expression between responders and non-responders to treatment.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Root et al. (2024) studied this question.

synapsesocial.com/papers/68e757b1b6db6435876cfa67 https://doi.org/10.1158/2767-9764.25352056.v1

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 3 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy2024
2Supplementary Figure 3 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy2024
3Supplementary Figure 1 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy2024
4Supplementary Figure 1 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy2024
5FIGURE 5 from Single-Cell CD4 and CD8 T-Cell Secretome Profiling Reveals Temporal and Niche Differences in Acute Myeloid Leukemia Following Immune Checkpoint Blockade Therapy2024