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Abstract Background Cancer is closely associated with both cardiovascular disease and lifestyle. We aimed to determine the relationship of the Life’s Essential 8 (LE8) score, which is an updated measure of cardiovascular health (CVH), with the presence of cancer among US adults. Methods This population-based cross-sectional study analyzed data on adults aged ≥ 20 years from the NHANES (National Health and Nutrition Examination Survey) program obtained during 2005–2018. LE8 scores range from 0 to 100, and they were obtained from measurements based on definitions reported by the American Heart Association. The scores were subdivided into health behaviors and health factors scores, and further categorized into low (0–49), moderate (50–79), and high (80–100) scores, which corresponded to poor, moderate, and optimal CVH, respectively. Multivariable logistic and restricted cubic-spline models were used to assess the association between the LE8 score and cancer. The correlation between the LE8 score and cancer among different populations was analyzed in different subgroups. Results The 24,969 participants (weighted mean age = 47.63 years, 95% confidence interval CI = 47–48 years) included 13,025 females (weighted percentage WP = 52%, 95% CI = 52–53%) and 2,403 patients diagnosed with cancer (WP = 10%). The weighted mean LE8 score of the study population was 67.84 (95% CI = 67–68). After adjusting for potential confounders, the LE8 score was not associated with the cancer risk, and there was no nonlinear dose–response relationship. In the subgroup analyses, the negative correlation between LE8 score and cancer was significantly stronger among those aged 20–49 years. The blood glucose and nicotine exposure score components of LE8 had significant negative correlations with the cancer risk. Conclusions CVH was strongly negatively correlated with the risk of early-onset cancer. Encouraging optimal CVH and a healthy lifestyle may be effective in reducing the risk of early-onset cancer.
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