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Abstract Background The burden of gastric cancer (GC) should be further clarified worldwide, and helped us to understand the current situation of GC. Methods In the present study, we estimated disability-adjusted life-years (DALYs) and mortality rates attributable to several major GC risk factors, including smoking, dietary risk, and behavioral risk. In addition, we evaluated the incidence rate and trends of incidence-based mortality (IBM) due to GC in the United States (US) during 1992–2018. Results Globally, GC incidences increased from 883,395 in 1990 to 1,269,805 in 2019 while GC-associated mortality increased from 788,316 in 1990 to 957,185 in 2019. In 2019, the age-standardized rate (ASR) of GC exhibited variations around the world, with Mongolia having the highest observed ASR (43.7 per 100,000), followed by Bolivia (34 per 100,000) and China (30.6 per 100,000). A negative association was found among estimated annual percentage change (EAPC) and ASR (age-standardized incidence rate (ASIR): r = − 0.28, p < 0.001; age-standardized death rate (ASDR): r = − 0.19, p = 0.005). There were 74,966 incidences of GC and 69,374 GC-related deaths recorded between 1992 and 2018. The significant decrease in GC incidences as well as decreasing trends in IBM of GC were first detected in 1994. The GC IBM significantly increased at a rate of 35%/y from 1992 to 1994 (95% CI 21.2% to 50.4%/y), and then begun to decrease at a rate of − 1.4%/y from 1994 to 2018 (95% CI − 1.6% to − 1.2%/y). Conclusion These findings mirror the global disease burden of GC and are important for development of targeted prevention strategies.
Wu et al. (Sat,) studied this question.