Mp08-17 Outcomes of Invasive Primary Urethral Cancer in Women (Ipuc): An Analysis From the National Cancer Database

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP08)1 May 2024MP08-17 OUTCOMES OF INVASIVE PRIMARY URETHRAL CANCER IN WOMEN (IPUC): AN ANALYSIS FROM THE NATIONAL CANCER DATABASE Mohammad Arfat Ganiyani, Vivek Podder, Arjun Pon Avudaiappan, Pushan Prabhakar, Atulya Aman Khosla, Shahzaib Ahmad, Ahmad Ozair, Muni Rubens, Mukesh Roy, Murugesan Manoharan, and Rohan Garje Mohammad Arfat GaniyaniMohammad Arfat Ganiyani , Vivek PodderVivek Podder , Arjun Pon AvudaiappanArjun Pon Avudaiappan , Pushan PrabhakarPushan Prabhakar , Atulya Aman KhoslaAtulya Aman Khosla , Shahzaib AhmadShahzaib Ahmad , Ahmad OzairAhmad Ozair , Muni RubensMuni Rubens , Mukesh RoyMukesh Roy , Murugesan ManoharanMurugesan Manoharan , and Rohan GarjeRohan Garje View All Author Informationhttps://doi.org/10.1097/01.JU.0001008780.87855.57.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: IPUC is exceedingly rare in women, and there is no established standard treatment approach. Histologic presentation and anatomical differences in the female urethra, compared to males, can influence oncological outcomes. Due to lack of prospective clinical trial data, the impact of various treatment modalities on survival outcomes is unknown. This study seeks to investigate the influence of different treatment approaches and histologic subtypes on survival rates in women diagnosed with IPUC. METHODS: This retrospective study utilized the National Cancer Database from 2004 to 2020 and followed STROBE guidelines. Our primary analytic cohort included women diagnosed with IPUC based on the TNM stage (T2-T4, N0-N2) without evidence of distant metastases. We included patients with adenocarcinoma (AD), squamous (SQ), and urothelial (UC) histology. Treatment approaches included perioperative systemic therapy (PST) combined with definitive surgery, concurrent chemoradiation (CR), surgery only (S), and systemic therapy only (ST). We utilized Kaplan-Meier survival analysis and the Cox Proportional Model to evaluate the effects of various histological subtypes and treatment approaches on survival outcomes. RESULTS: We identified 682 women diagnosed with IPUC, of which 200 (29.3%), 244 (35.8%), and 238 (34.9%) had AD, SQ, and UC histology, respectively. We found that 14.3% of patients received PST, 25.5% got CR, 33.2% underwent S, and 27% received ST. The median overall survival (OS) was significantly different (p<0.001) based on the treatment approach, and was 51.29 months (CI: 33.18 -142.75) with PST, 48.79 months (CI: 39.46- 90.48) with CR, 47.7 months (CI: 41.43-61.7) with S, and 19.81 months (CI:16.66-25.92) with ST. The median OS was 35.8 Months (CI: 26.1-42.6) in women with AD histology as compared to 32.3 months (CI:26.5-44.5) and 20.8 months (CI:17.0-26.6) with SQ and UC (p=0.04), respectively. CONCLUSIONS: Treatment approaches with either systemic therapy combined with definitive surgery or concurrent chemoradiation enhanced survival outcomes, highlighting the significance of a multimodal approach for women with IPUC. Adenocarcinoma and Squamous histology showed significantly better survival compared to the urothelial subtype. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e122 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Mohammad Arfat Ganiyani More articles by this author Vivek Podder More articles by this author Arjun Pon Avudaiappan More articles by this author Pushan Prabhakar More articles by this author Atulya Aman Khosla More articles by this author Shahzaib Ahmad More articles by this author Ahmad Ozair More articles by this author Muni Rubens More articles by this author Mukesh Roy More articles by this author Murugesan Manoharan More articles by this author Rohan Garje More articles by this author Expand All Advertisement PDF downloadLoading ...