Mp34-03 Underrepresentation of Minority Populations in Stress Urinary Incontinence Clinical Trials

You have accessJournal of UrologyDiversity, Equity & Inclusion: Health Equity & Outcomes II (MP34)1 May 2024MP34-03 UNDERREPRESENTATION OF MINORITY POPULATIONS IN STRESS URINARY INCONTINENCE CLINICAL TRIALS Joo Lee, Phillip Westbrook, Tal Cohen, and Igor Inoyatov Joo LeeJoo Lee , Phillip WestbrookPhillip Westbrook , Tal CohenTal Cohen , and Igor InoyatovIgor Inoyatov View All Author Informationhttps://doi.org/10.1097/01.JU.0001008876.78012.90.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Stress urinary incontinence (SUI) affects a substantial portion of adult women, with prevalence estimates ranging from 4% to 35%. While SUI has been well-documented in white populations, there is limited information available regarding its prevalence in other racial and ethnic groups. As a result, limited evidence is available to investigate potential racial disparities in SUI severity, treatment-seeking behavior, and treatment outcomes. Historically, minority groups have been underrepresented in clinical trials. This study aims to assess the enrollment rates of minority patients in SUI clinical trials. METHODS: We conducted a search of the ClinicalTrials.Gov database for completed clinical trials from 2008 to 2022 related to female stress urinary incontinence in the United States. Studies were filtered for the condition "stress incontinence female" and location limited to the United States. Only interventional studies with completed results were included. Minority groups in this study were defined as African-American (AA) and Hispanic patients. RESULTS: We identified thirty completed clinical trials focused on interventions for female stress urinary incontinence, with a total enrollment of 6,688 patients. Black/African American patients comprised only 6.2% of the total enrollment, while Hispanic patients accounted for 8.5%. Among the identified studies, approximately a quarter (23%) of studies did not provide demographic information of their patient cohort. In studies that did report demographic information, an average of 76% of participants identified as non-Hispanic white, 7% as Black/African American, and 7.8% as Hispanic. CONCLUSIONS: The majority of clinical trials investigating interventions for female SUI demonstrate a marked underrepresentation of minority groups. Study enrollment is predominantly skewed toward non-Hispanic white women. This lack of adequate representation may compromise the generalizability of trial results to minority populations and potentially lead to suboptimal outcomes. Future clinical trials should aim to include a more representative cross-section of the U.S. population with specific focus on enrollment of minority populations. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e571 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Joo Lee More articles by this author Phillip Westbrook More articles by this author Tal Cohen More articles by this author Igor Inoyatov More articles by this author Expand All Advertisement PDF downloadLoading ...