A higher left atrial to ventricular volume ratio (LA:LV) was associated with increased odds of diastolic dysfunction (OR 2.6; 95% CI 2.1-3.3) and explained 29% of variance in VO2peak (P<0.001).
Cohort (n=1,348)
The LA:LV ratio is associated with diastolic dysfunction and filling pressures, and helps differentiate fitness levels in individuals with enlarged left atria, potentially distinguishing physiological from pathological enlargement.
Effect estimate: OR 2.6 (95% CI 2.1, 3.3)
Abstract Aims Left atrial (LA) and ventricular (LV) remodelling is thought to be balanced in healthy individuals, and the LA end-systolic volume (LAV) to LV end-diastolic volume (LVEDV) ratio (LA:LV) could help discriminate between pathological and physiological LA enlargement. We aimed to assess LA:LV and its associations with age, sex, and cardiovascular risk factors HbA1C, body mass index (BMI), systolic blood pressure, and peak oxygen uptake (VO2peak). The association to measures of LV diastolic function and filling pressures were compared with LAV and LA reservoir strain. Methods and results Cardiopulmonary exercise testing and measurement of risk factors 10 years apart and echocardiography at follow-up was performed in 1348 healthy adults 52% women, mean (SD) age 59 (12) years prospectively included in a large population study. All risk factors were significantly associated with LA:LV in univariate analyses, while BMI and VO2peak were significantly associated with LA:LV in adjusted models. A higher LA:LV was associated with increased odds ratio (OR) of diastolic dysfunction OR (95% CI) 2.6 (2.1, 3.3). Measures of LV filling pressures were more closely associated with LA:LV than LAV and LA reservoir strain, but LA reservoir strain was more closely related to some diastolic function measures. In individuals with LAV 34 mL/m2, the LA:LV explained 29% of variance in VO2peak (P 0.001). Conclusion A higher LA:LV was associated with, and may improve, assessment of diastolic dysfunction and filling pressures. The LA:LV differentiates VO2peak in individuals with enlarged LAV and may have a role in evaluating whether LA enlargement reflects pathology.
Sabo et al. (Mon,) conducted a cohort in Healthy individuals (n=1,348). Left atrial to ventricular volume ratio (LA:LV) vs. LAV and LA reservoir strain was evaluated on Diastolic dysfunction (OR 2.6, 95% CI 2.1, 3.3). A higher left atrial to ventricular volume ratio (LA:LV) was associated with increased odds of diastolic dysfunction (OR 2.6; 95% CI 2.1-3.3) and explained 29% of variance in VO2peak (P<0.001).