F-40 | Hemodynamic Outcomes of Percutaneous Pulmonary Thrombectomy in Intermediate High Risk Acute Pulmonary Embolism : A Single Center Analysis

Pulmonary embolism (PE), particularly of intermediate risk, presents a significant challenge in clinical management. This study aims to evaluate the hemodynamic outcomes of percutaneous mechanical thrombectomy in patients with intermediate-risk acute pulmonary embolism. This retrospective single-center study analyzed 56 hospitalized patients with acute pulmonary thrombosis or embolism (APE) who underwent mechanical thrombectomy based on ESC guidelines. The primary outcomes were the hemodynamic parameters. Secondary outcomes included other Comorbidities. The mean age of the patients was 61.89 years, with a slight female predominance (53.6%). The mean RV/LV ratio on CT chest angiography was 1.55. Post-procedure, there was a significant reduction in PA systolic and diastolic pressures (mean decrease of 11.643 mmHg and 3.411 mmHg, respectively). The mean length of hospital stay was 5.11 days. Adverse events including bleeding had an incidence of 8.9% and a mortality rate of 3.6%. The majority of patients (83.9%) were classified as intermediate-high risk, and the time to catheterization lab from admission varied, with 35.7% receiving intervention within 24 hours. Mechanical thrombectomy in intermediate-risk pulmonary embolism patients appears to significantly improve hemodynamic parameters, with a notable reduction in PA pressures and Heart rate. The procedure shows a favorable safety profile with low rates of bleeding and mortality. However, larger multicenter trials are needed to confirm further define the role of mechanical thrombectomy in the management of intermediate-risk pulmonary embolism.