C-17 | Efficacy Between Optical Coherence Tomography and Angiography Guided Pci Among Coronary Artery Disease Patients: An Updated Meta-Analysis of Randomized Controlled Trials

Clinical outcomes post optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI), and angiography-guided PCI are not well known, with limited data and studies to date. We aim to evaluate the efficacy of OCT-guided PCI versus angiography-guided PCI among patients with coronary artery disease. A systematic literature search was performed in electronic databases from inception to 15th September 2023, including only randomized controlled evaluating OCT vs Angiography guided PCI among CAD patients. A total of 11 randomized controlled trials with 5103 patients (2549 in OCT group and 2554 in angiography-guided PCI group) were included in the analysis. The pooled analysis shows that the OCT group were having a non-significant decline in major adverse cardiovascular events (OR, 0.82(95%CI: 0.60-1.11), all-cause mortality (OR, 0.72(95%CI: 0.49-1.04), cardiovascular death (OR, 0.62(95%CI: 0.37-1.04), and a significant reduction in stent thrombosis (OR, 0.58(95%CI: 0.34-0.99) compared with angiography guided PCI. However, the risk of target vessel revascularization (OR, 0.95(95%CI: 0.72-1.26) was comparable between both groups of patients. Among patients undergoing PCI, OCT guidance resulted in relatively favorable outcomes compared with angiography-guided PCI.