FIGURE 5 from Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition

Systemic β-AR activation through either acute exercise or ISO infusion evoke similar transcriptomic and surface phenotype shifts among ex vivo expanded Vγ9Vδ2+ T-cells. A, The percentage of activating, inhibitory, and chemokine receptors among expanded Vγ9Vδ2+ T-cells before (REST) and during (EX) exercise or ISO infusion. (n = 8). Statistical significance set as *, P B) exercise or (C) ISO infusion. Graphs show enriched upregulated (blue) and downregulated (red) pathways as well as the percentage of DEGs contributing to each mechanism. Statistical significance set as FDR ≤ 0.25. Data are represented as mean.