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Introduction: This theoretical narrative perspective will focus on pointing out the psychobiological factors which are involved in the genesis and treatment of personality prominent traits and disorders. Material and method: After a suitable search, mainly in PubMed and Psyc Info Journal databases, the number of selected quality publications is n= 95. The reduced sample sizes and numerous research designs that are merely exploratory or observational are its main limitations. Results and discussion: Regarding the psychopathology of personality neurodevelopment, environmental and genetic factors as well as neurotransmitter impairments are confirmed to be involved. Of interest are the endophenotypic perspective, endocannabinoid system and hypothalamus-regulated endocrine axes, among others. Neuroimmunology predicts important clinical and therapeutic innovations, but they are not a reality yet. It has been suggested that only with psychological interventions of various types is there symptomatic improvement as well as a favourable effect on stress-related epigenetic mechanisms. Psychopharmacotherapy continues to be useful, mainly off-label, with antipsychotics, anticonvulsants and opioid antagonists. Conclusions: In the absence of support from convincing qualified evidence, both users and health physicians usually prefer any type of psychological intervention to tackle complex personality clinical dysfunctions, without excluding complementary psychopharmacotherapy.
José Manuel Bertolín Guillén (Sat,) studied this question.