A high triglyceride-glucose index (≥ 8.84) independently predicted an increased risk of 10-year major adverse cardiovascular events (OR 1.64) in non-diabetic acute MI patients undergoing PCI.
Cohort (n=375)
No
Does a high Triglyceride-Glucose (TyG) index predict major adverse cardiovascular events in non-diabetic patients with acute myocardial infarction undergoing percutaneous coronary intervention?
An elevated Triglyceride-Glucose (TyG) index is an independent predictor of 10-year major adverse cardiovascular events in non-diabetic patients with acute myocardial infarction undergoing percutaneous coronary intervention.
Effect estimate: OR 1.64 (95% CI 1.22-2.21)
p-value: p=0.002
OBJECTIVE: This study aimed to explore the association between the triglyceride-glucose (TyG) index and major adverse cardiovascular events (MACE) over a ten-year period in non-diabetic patients with acute myocardial infarction (MI) undergoing primary percutaneous coronary intervention (PCI). METHODS: We included 375 consecutive non-diabetic patients presenting with acute MI who underwent primary PCI. The TyG index was calculated and patients were divided based on a cut-off value of ≥ 8.84 into high and low TyG index groups. The incidence of MACE, including all-cause mortality, target vessel revascularization, reinfarction, and rehospitalization for heart failure, was assessed over 10 years. RESULTS: Over the next 10 years, patients who underwent PCI for acute MI experienced a significantly higher incidence of MACE in the group with a high TyG index (≥ 8.84) (P = 0.004). Multivariable analysis revealed that the TyG index independently predicted MACE in these patients odds ratio = 1.64; 95% confidence interval (CI): 1.22-2.21; P = 0.002. Analysis of the receiver operating characteristic curve indicated that the TyG index effectively predicted MACE in patients with acute MI following PCI, with an area under the curve of 0.562 (95% CI: 0.503-0.621; P = 0.038). CONCLUSION: This study established a correlation between high TyG index levels and an elevated risk of MACE in non-diabetic patients with acute MI. The findings suggest that the TyG index could be a reliable indicator of clinical outcomes for non-diabetic acute MI patients undergoing PCI.
Uğur Köktürk (Mon,) conducted a cohort in Acute myocardial infarction in non-diabetic patients (n=375). High Triglyceride-Glucose (TyG) index vs. Low TyG index (< 8.84) was evaluated on Major adverse cardiovascular events (MACE) (OR 1.64, 95% CI 1.22-2.21, p=0.002). A high triglyceride-glucose index (≥ 8.84) independently predicted an increased risk of 10-year major adverse cardiovascular events (OR 1.64) in non-diabetic acute MI patients undergoing PCI.