472-P: Molecular Pathogenesis of Sex-Specific Vascular Contributions to Cognitive Impairment and Dementia and in Type 1 Diabetes

Introduction this diabetic increase was no different between males and females. Noticeably, mitochondrial and complex III ROS production, Chk2, and tau phosphorylation all had similar increases in cerebral cortex tissues from both male and female diabetic mice. Conclusion: Taken together, we conclude that T1D may cause greater mitochondrial complex III ROS production, greater DNA damage and greater Chk2 phosphorylation in male CASM tissues, thereby leading to more serious cognitive impairment and memory loss in male than female T1D. Disclosure E. Santos: None. S. Khatoon: None. Y. Zheng: None. Y. Wang: None. Funding R01HL122865R03AG070784R01HL108232