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Introduction Spearman correlations tested associations between VFAT and metabolic indices. Linear regression with adjustment for age, sex and inclusion of a VFAT-by-ancestry interaction term examined ancestry differences in Si and ISR. Results: AYA (n= 51 SA, 39 W, 25 AA) were of similar age (median (IQR); SA 20.3y (18.9, 21.5); W 19.3y (18.3, 21.1); AA 19.0y (18.0, 20.4)), BMIZ (mean ± SD; SA 1.21 ± 0.53; W 1.14 ± 0.57; AA 1.38 ± 0.60), and BMI (SA 27.9 kg/m2 (25.1, 29.4); W 25.9 (24.6, 29.7); AA 27.3 (25.3, 35.5)), but differed by female sex: SA 52.9%; W 56.4%; AA 88.0% (p=0.009). SA had higher VFAT (97.5 cm2 (82.0,121.0)) than W (87.2 (64.1,108.0) and AA (75.0 (51.2,102), p= 0.029. One cm2 increase in VFAT associated with 41% lower Si (p=0.03) and 82% greater increase in ISR (p0.001) in SA compared to W. Compared to AA, for 1cm2 VFAT increase, SA had similar Si decrease, but 82% greater ISR increase (p=0.004). Conclusion: Among AYA of similar BMI, SA had higher VFAT than W and AA. However, for similar increase in VFAT, SA had a greater reduction in Si and higher ISR increase compared to W. SA had a similar reduction in Si compared to AA, but again a greater increase in ISR. Thus, the higher T2DM risk in SA may be due to greater hyperinsulinemic compensation, resulting in beta cell exhaustion. Disclosure D. Stefanovski: None. A. Kelly: None. T.A. Hitt: None. B.S. Zemel: None. S.N. Magge: None. Funding National Institutes of Health (R01DK115648); National Institutes of Health (UL1TR001878); National Institutes of Health (UL1TR001079)
Stefanovski et al. (Fri,) studied this question.