1688-P: Type 2 Diabetes Remission after Metabolic and Bariatric Surgery—A Systematic Review and Meta-analysis Comparing Less Obese and Severely Obese Individuals

Introduction 35 kg/m2 or ≥35 kg/m2). The primary outcome was diabetes remission (HbA1c 6.5% without antidiabetic medication) at different post-surgery intervals, with analysis of HbA1c and BMI changes. We used meta-regression for between-group comparisons and assessed potential bias. Results: Eighty-one studies were included (23 with BMI 35 kg/m2, 58 with BMI ≥35 kg/m2). At 12 months, diabetes remission rates were 0.59 (95% CI 0.49 to 0.70) for BMI 35 kg/m2, and 0.61 (0.55 to 0.67) for BMI ≥35 kg/m2. No significant between-group differences were observed at 12 months (adjusted weighted mean difference WMD −0.01, 95% CI −0.14 to 0.12), 24 months (adjusted WMD −0.04, 95% CI −0.29 to 0.21), 36 months (adjusted WMD 0.00, 95% CI −0.22 to 0.23), and ≥60 months (adjusted WMD −0.02, 95% CI −0.25 to 0.22). Achieved HbA1c levels were comparable, but BMI remained higher in those with BMI ≥35 kg/m2. Conclusions: Our study demonstrates that diabetes remission after MBS is similar between individuals with BMI 35 kg/m2 and BMI ≥35 kg/m2 over the long-term follow-up. Disclosure J. Bae: None. N. Kim: None.