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The article consistently examines the discovery of the biophysical properties of nitric oxide (NO) and provides some scientific data on the metabolism of NO. The aim was to consider NO as a biological marker in the diagnostic algorithm and its therapeutic use. Conclusion . The experience accumulated to date indicates the effectiveness of NO in such areas as transplantology, cardiology, endocrinology, andrology, sports medicine, etc. The experience of using NO in patients with post-COVID syndrome and pulmonary embolism is reviewed. It is necessary to organize multicenter studies to assess the effectiveness of NO therapy more deeply and develop criteria for selecting its dosage and duration of treatment.
А. Г. Чучалин (Sun,) studied this question.