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Abstract OBJECTIVE To demonstrate hypercoagulability with a benchtop viscoelastic monitor in cats with congestive heart failure (CHF) and/or aortic thromboembolism (ATE) compared to controls. METHODS 97 cats were enrolled throughout this prospective observational cohort study from September 2022 through October 2023. Cats were grouped by diagnosis of CHF, ATE, ATE plus CHF, or controls. Enrollment required diagnosis of heart disease and no previous antithrombotic therapy. The results of viscoelastic testing with the benchtop viscoelastic coagulation monitor (VCM Vet VCM; Entegrion) were compared between groups using factorial analysis of variance. RESULTS Cats with heart disease had significantly higher clot times when compared to controls (control: mean, 285.3 SD, 172.6; CHF: mean, 391.7 SD, 106.8; ATE: mean, 415.9 SD, 109.2; and ATE plus CHF: mean, 368.6 SD, 232.6). Heart disease cats were noted to have significantly lower 45-minute lysis index values (control: median, 100 range, 93 to 100; CHF: median, 99 range, 89 to 100; ATE: median, 98 range, 88 to 100; and ATE plus CHF: range, 98 91 to 100). Age was a covariate to this variable, and when applied to analysis, statistical significance was lost. No significant difference in any other variables were noted. CLINICAL RELEVANCE The hypercoagulability of ATE and CHF cats was not detected by the VCM. Further research with other coagulation monitors is required in this population.
Moses et al. (Wed,) studied this question.