Single-nucleus transcriptomics reveals adrenergic and STAT3 signalling in paradoxical low-flow low-gradient-specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment

Journal Article Accepted manuscript Single-nucleus transcriptomics reveals adrenergic and STAT3 signaling in paradoxical low-flow low-gradient -specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment Get access Xingbo Xu, Xingbo Xu Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Correspondence: Ph.D. Xingbo Xu, Heart Research Building (DZHK), Department of Cardiology and Pneumology, University Medical Center of Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany, Telephone: +49-(0)551-3963633, Email: xingbo.xu@med.uni-goettingen.de; Dr. Gerd Hasenfuß, MD, Department of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany, Telephone: +49-(0)551-3967601, Fax: +49-(0)551-3967601, Email: hasenfus@med.uni-goettingen.de https://orcid.org/0000-0002-8249-5507 Search for other works by this author on: Oxford Academic PubMed Google Scholar Xiaoying Tan, Xiaoying Tan German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, GermanyDepartment of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Baolong Cui, Baolong Cui Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Niels B Paul, Niels B Paul Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyDepartment of Medical Bioinformatics, University Medical Center Göttingen, Goldschmidtstraße 1, 37077 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Manar Elkenani, Manar Elkenani Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Bo E Beuthner, Bo E Beuthner Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Weichao Li, Weichao Li Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Belal A Mohamed, Belal A Mohamed Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Moritz Schnelle, Moritz Schnelle German Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, GermanyDepartment of Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Miriam Puls, Miriam Puls Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany https://orcid.org/0000-0001-5540-1264 Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Elisabeth M Zeisberg, Elisabeth M Zeisberg Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Zeisberg, Michael Zeisberg Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Tim Beißbarth, Tim Beißbarth Department of Medical Bioinformatics, University Medical Center Göttingen, Goldschmidtstraße 1, 37077 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Karl Toischer, Karl Toischer Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerd Hasenfuß Gerd Hasenfuß Clinic for Cardiology and Pulmonology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, GermanyGerman Center for Cardiovascular Research (DZHK), Partner Site Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany Correspondence: Ph.D. Xingbo Xu, Heart Research Building (DZHK), Department of Cardiology and Pneumology, University Medical Center of Göttingen, Robert-Koch-Str. 42a, 37075 Göttingen, Germany, Telephone: +49-(0)551-3963633, Email: xingbo.xu@med.uni-goettingen.de; Dr. Gerd Hasenfuß, MD, Department of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August-University, Robert-Koch-Str. 40, 37075 Göttingen, Germany, Telephone: +49-(0)551-3967601, Fax: +49-(0)551-3967601, Email: hasenfus@med.uni-goettingen.de Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, cvae137, https://doi.org/10.1093/cvr/cvae137 Published: 29 June 2024 Article history Received: 15 February 2024 Revision received: 22 April 2024 Accepted: 17 June 2024 Published: 29 June 2024