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Abstract Background Postoperative atrial fibrillation (POAF) is one of the most common types of acute AF and can complicate the treatment course of approximately one third of patients undergoing cardiac surgery. Sodium‐glucose cotransporter‐2 (SGLT2) inhibitors are among the newest antidiabetic drugs which can be therapeutic options for preventing POAF by different mechanisms. Methods Empagliflozin to Prevent POAF (EMPOAF) is an interventional, investigator‐initiated, double‐blind, placebo‐controlled, multicenter, randomized controlled trial which will be conducted in two referral teaching cardiology hospitals in Tehran. Four‐hundred ninety‐two adult patients who are scheduled for elective isolated coronary artery bypass graft (CABG) surgery will be randomly assigned to one of the groups of intervention (empagliflozin 10 mg daily) or placebo starting at least 3 days before surgery until discharge. Key exclusion criteria are a history of diabetes mellitus, AF, ketoacidosis, or recurrent urinary tract infections along with severe renal or hepatic impairment, unstable hemodynamics, and patients receiving SGLT2 inhibitors for another indication. The primary outcome will be the incidence of POAF. Key secondary endpoints will be the composite rate of life‐threatening arrhythmias, postoperative acute kidney injury, hospitalization length, in‐hospital mortality, stroke, and systemic embolization. Key safety endpoints will be the rate of life‐threatening and/or genitourinary tract infections, hypoglycemia, and ketoacidosis. Conclusions EMPOAF will prospectively evaluate whether empagliflozin 10 mg daily can reduce the rate of POAF in patients undergoing elective CABG. Enrolment into this study has started by November 2023 and is expected to be ended before the end of 2025.
Aghakouchakzadeh et al. (Sun,) studied this question.