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e13795 Background: Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a life expectancy of less than a year post-diagnosis despite multimodal therapy. Recent Advancements have significantly prolonged the survival period. However, barriers still exist in survivorship care for minority populations. We aim to delve deeper into understanding these disparities in survival outcomes based on demographic characteristics. Methods: We included patients diagnosed with Glioblastoma Multiforme in the National Cancer Database from 2004-2021. Demographic characteristics were taken into account. Kaplan Meir curve and Log-rank test were utilized to compare survival rates in different groups. Results: A total of 169793 patients were identified from 2004-2021 with an increased incidence in the age groups 64-74. Overall survival has increased steadily since 2011 (2004-2011 OS 8.84 months Vs 10.55 months from 2011-2021 p-value=0.058). Age is an independent predictor of survival. The younger the patient, the better the survival period. Young adults (<50 years) have a better OS of 19.22 months with a decline in age 50-64 (13.22 months), and age 64-74(8.18 months, p value <0.001). Worsen OS is seen in the geriatric population (3.75 months). African Americans (AA) have a better survival period as opposed to Whites (10.91 months Vs. 9.63 months, p value <0.001). Multivariate analysis revealed that age, race and the time frame of diagnosis (before 2011 vs after 2011) have a major role in predicting survival. Conclusions: Demographic disparities seen in the survival patterns, with worse outcomes seen in elderly, White people. Future research directions should be emphasized in the marginalized group White, elderly population. Table: see text
Ayoobkhan et al. (Sat,) studied this question.