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This study was carried out to determine the effects of Bryophyllum pinnatum leaf extract on Prostrate specific antigen, Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT), levels of albino rats.Thirty-five albino rats were randomly divided into five groups with seven rats in each group (n=7); Control (C) received normal feed only.Group 1 was administered with Bryophyllum pinnatum leaf extract 100 mg/kg, Group 2: Bryophyllum pinnatum extract 150 mg/kg, and Group 3 received Bryophyllum pinnatum leaf extract 200 mg/kg.Group 4: received Bryophyllum pinnatum leaf extract 250 mg/kg.This lasted for 28 days.Group 3 and 4 showed significantly decreased PSA (1.08±0.29ng/ml;1.18±0.32ng/ml)AST (14.19±0.64iu/l,14.05±0.71iu/l)and ALT (10.12±0.73iu/l,10.98± 0.98iu/l) when compared with the control (PSA 2.08±0.29ng/ml,AST 16.41±0.93,ALT 13.77±0.51)respectively at p < 0.05.Bryophyllum pinnatum leaf extract has a hepatoprotective and prostrate protective effect.
Ekom et al. (Thu,) studied this question.