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Multiplex IHC showing T cell subpopulations in the tumor microenvironment of HNSCC PDX (YHIM-3003) tumor after combination treatment of amivantamab and pembrolizumab. A, Whole slide images of tumor scan showing segmentation of tissues and cells. Helper CD4 and cytotoxic CD8 T cells were marked with FoxP3 (regulatory T cells) and GZMB (active cytotoxic T cells). Cancer cells were stained with Pan-CK. B, Stained whole slide images were quantified and presented in bar plots showing GZMB+ CD8 T cells and regulatory T cells in the tumor microenvironment, tumor nest and stroma in different treatment groups. Proportion of GZMB+ CD8 T cells in the total TME and the tumor nest was significantly increased in the combination group (P
Lim et al. (Wed,) studied this question.