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Nephropathy is most common complication in type 2 diabeticsubjects. Urinary nephrin is a podocyte specific protein, can be serve as a predict early nephropathy and its progression of diabetic nephropathy. A total 90 participants included were sub grouped as 60 cases and 30 healthy controls, a biochemical, clinical and experimental parameters were analyzed for all the study subjects. The data was interpreted by using statistics software SPSS and 0.05 was statistically significant. There were significantly increased levels of FBS, PPBS and glycated haemoglobin in type 2 diabetic cases when compared to controls. The urea, creatinine, uric acid and microalbumin were significantly elevated in type 2 diabetic with microalbuminuria when compared to type 2 diabetic with normoalbuminuria and controls. Additionally the urinary nephrin was significantly elevated in both groups of type 2 diabetics when compared to controls. This study suggests determination of urinary nephrin can be used as an early predictable and prognostic marker for nephropathy in patients with type 2 diabetics.
Chittaragi et al. (Tue,) studied this question.