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MRSI-based nosological images have been previously applied to monitor therapy response in a murine model of GL261 glioblastoma using a commercially available MRSI-PRESS sequence. Due to the heterogeneous nature of glioblastomas, increasing spatial resolution could provide additional insight into changes related to therapy response. The in-house implementation of the MRSI-semi-LASER sequence, using weighted acquisition, has allowed us a 20% slice thickness reduction without losing relevant spectral quality. Moreover, different k-space sampling strategies have been evaluated showing significant SNR increase with elliptical sampling, which may allow further increase in the spatial resolution or reduction in the total experimental time.
Javed et al. (Wed,) studied this question.
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