Nursing Interventions and Biochemical Markers in Early Detection of Neonatal Sepsis

Aim: This study aims to explore the role of nurses and the use of biochemical markers in the management of neonatal sepsis. Methods: A comprehensive literature review was conducted to analyze current research on the roles of nurses in neonatal sepsis management and the utility of biochemical markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-6, IL-8, IL-10), and soluble CD14 subtype presepsin (sCD14-ST) in diagnosing and monitoring neonatal sepsis. Studies focusing on clinical trials, observational studies, and meta-analyses published between 2000 and 2024 were included. Results: Nurses play a critical role in the early recognition and management of neonatal sepsis through vigilant monitoring, timely intervention, and effective communication with healthcare teams. Biochemical markers, particularly CRP and PCT, have shown promise in aiding early diagnosis and monitoring treatment response. IL-6, IL-8, IL-10, and sCD14-ST have also demonstrated potential as adjunctive markers in differentiating sepsis from non-infectious conditions. Conclusion: The integration of nurses in the multidisciplinary care team is crucial for improving outcomes in neonatal sepsis. Biochemical markers provide valuable adjuncts to clinical assessment, facilitating early diagnosis, appropriate antibiotic use, and monitoring of treatment efficacy. Further research is needed to standardize protocols for marker use, optimize diagnostic accuracy, and enhance the overall management of neonatal sepsis.