August 28, 2024

Cognitive progression independent of relapse in multiple sclerosis

TFTom FuchsAmsterdam Neuroscience MSMenno M. SchoonheimAmsterdam Neuroscience RZRobert ZivadinovYale University

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Abstract

Substantial physical-disability worsening in relapsing-remitting multiple sclerosis (RRMS) occurs outside of clinically recorded relapse. This phenomenon, termed progression independent of relapse activity (PIRA), is yet to be established for cognitive decline.

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Fuchs et al. (Wed,) studied this question.

synapsesocial.com/papers/68e5a818b6db6435875425c0 https://doi.org/https://doi.org/10.1177/13524585241256540

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1Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis2019 · 170 citations
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3Neurological update: cognitive rehabilitation in multiple sclerosis2021 · 59 citations
4Patients and neurologists have different perceptions of multiple sclerosis symptoms, care and challenges2021 · 54 citations
5Defining progression independent of relapse activity (PIRA) in adult patients with relapsing multiple sclerosis: A systematic review✰2023 · 42 citations

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