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Abstract Background: Synovial sarcoma (SS) is a rare cancer that is less common in the head and neck area. Because of its low incidence in this anatomical area, early diagnosis is difficult, and optimal treatment strategies remain uncertain. Here, we present a case of SS in the oropharynx. Case presentation: The patient, a 70-year-old male, was admitted to the hospital with intermittent pain in the left gingiva, head, and face, and experienced dysphagia. biopsy proved to be SS. The patient did not agree to the surgery because of the extent of the resection. Thus, combined treatment based on radiotherapy and chemotherapy was performed. Post-treatment evaluations revealed significant reductions in the size of the oral pharynx lesion and lymph nodes, achieving a therapeutic response assessed as partial remission (PR). Conclusions: The intricate anatomical landscape of the head and neck region poses significant challenges for the surgical management of SS. Combined treatment based on radiotherapy and chemotherapy offers avenues to achieve tumor regression for synovial sarcoma where surgery is not available.
Qi et al. (Mon,) studied this question.