Individuals with multiple sclerosis had similar hemodynamic responses to peak exercise compared to controls with similar peak VO2, with no significant interactions for MAP, SV, or Q.
Observational (n=42)
Do individuals with multiple sclerosis have different cardiovascular hemodynamic responses to peak exercise compared to controls with similar aerobic capacity?
Individuals with multiple sclerosis have similar hemodynamic responses to peak exercise as controls when matched for fitness, suggesting fitness rather than the disease itself determines these responses.
p-value: p=<0.01 for HR interaction
Abstract Multiple sclerosis (MS) is a chronic neurological condition resulting in decreased aerobic capacity (peak VO 2 ). The hemodynamic responses to peak exercise in MS are unknown. Further, it is unknown if the hemodynamic responses are due to disease or fitness. Therefore, the purpose was to compare hemodynamic response to peak exercise between individuals with and without MS, with similar peak VO 2 . Individuals with MS ( n = 21) and CON ( n = 21) underwent maximal incremental cycle exercise test to assess peak aerobic capacity (peak VO 2 ). Heart rate, stroke volume, cardiac output, and blood pressure were obtained every other minute of the exercise test. There were no significant group differences in peak VO 2 . All hemodynamic variables increased similarly from baseline to peak exercise in both MS and CON. There was a significant group by time interaction for HR in individuals with MS ( p < 0.01), accounted for by age, but no group by time interactions in MAP ( p = 0.78), SV ( p = 0.11), or Q ( p = 0.86). Our findings suggest that individuals with and without MS, with similar peak VO 2 , have similar hemodynamic responses to peak exercise. Our data suggest that fitness is a key underlying determinants of hemodynamics responses in individuals with MS.
Hibner et al. (Sun,) conducted a observational in Multiple sclerosis (n=42). Multiple sclerosis vs. Controls without MS was evaluated on Hemodynamic response to peak exercise (HR, SV, MAP, Q) (p=<0.01 for HR interaction). Individuals with multiple sclerosis had similar hemodynamic responses to peak exercise compared to controls with similar peak VO2, with no significant interactions for MAP, SV, or Q.