Key result
Multiple sclerosis does not alter peak exercise hemodynamics when matched for cardiorespiratory fitness.
Why the study?
Hemodynamic responses to peak exercise in multiple sclerosis and whether they are driven by disease or fitness remain unknown.
Does multiple sclerosis impair cardiovascular hemodynamic responses to peak exercise in individuals with similar aerobic capacity?
Cross-Sectional (n=42)
No
Does multiple sclerosis impair cardiovascular hemodynamic responses to peak exercise in individuals with similar aerobic capacity?
p-value: p=0.78 for MAP, p=0.11 for SV, p=0.86 for Q
Hemodynamic responses to exercise in individuals with MS match those of controls when matched for aerobic capacity, emphasizing that physical fitness is the key determinant of cardiovascular function in this population.
Fitness-matched MS and controls show comparable exercise hemodynamics; hypothesis-generating and requires prospective confirmation before practice change.
Multiple sclerosis (MS) is a chronic neurological condition resulting in decreased aerobic capacity (peak VO 2 ). The hemodynamic responses to peak exercise in MS are unknown. Further, it is unknown if the hemodynamic responses are due to disease or fitness. Therefore, the purpose was to compare hemodynamic response to peak exercise between individuals with and without MS, with similar peak VO 2 . Individuals with MS ( n = 21) and CON ( n = 21) underwent maximal incremental cycle exercise test to assess peak aerobic capacity (peak VO 2 ). Heart rate, stroke volume, cardiac output, and blood pressure were obtained every other minute of the exercise test. There were no significant group differences in peak VO 2 . All hemodynamic variables increased similarly from baseline to peak exercise in both MS and CON. There was a significant group by time interaction for HR in individuals with MS ( p < 0.01), accounted for by age, but no group by time interactions in MAP ( p = 0.78), SV ( p = 0.11), or Q ( p = 0.86). Our findings suggest that individuals with and without MS, with similar peak VO 2 , have similar hemodynamic responses to peak exercise. Our data suggest that fitness is a key underlying determinants of hemodynamics responses in individuals with MS.
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Hibner et al. (2024) conducted a cross-sectional in Multiple sclerosis (n=42). Multiple sclerosis vs. Individuals without multiple sclerosis (matched for similar peak VO2) was evaluated on Hemodynamic responses to peak exercise (group by time interactions for mean arterial pressure, stroke volume, and cardiac output) (p=p=0.78 for MAP, p=0.11 for SV, p=0.86 for Q). Individuals with and without multiple sclerosis, with similar peak VO2, exhibited similar hemodynamic responses to peak exercise, suggesting fitness rather than disease drives cardiovascular response.
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