Key result
Paradoxical MSNA increases during moderate cycling in HFpEF strongly correlate with lower relative VO2peak.
Why the study?
It was unknown whether sympathoexcitatory responses observed in heart failure with reduced ejection fraction are present in HFpEF and relate to peak oxygen uptake.
Does the sympathetic response to exercise correlate with exercise capacity in patients with HFpEF?
Population
13 patients with HFpEF, 17 comorbidity-matched controls, and 18 healthy controls
Comparison
HFpEF vs comorbidity-matched controls vs healthy controls during exercise
Design
Physiological study
Authors
Loading...
Sympathoexcitation may limit exercise capacity in HFpEF; hypothesis-generating for sympathetic-targeted interventions.
Observational (n=48)
Does the sympathetic response to exercise correlate with exercise capacity in patients with HFpEF?
Effect estimate: r = -0.72
p-value: p=<0.01
Patients with HFpEF exhibit paradoxical sympathoexcitation during dynamic exercise, which inversely correlates with their exercise capacity, suggesting a neurogenic limit on exercise tolerance.
Badrov et al. (2024) conducted an observational in Heart failure with preserved ejection fraction (HFpEF) (n=48). 1-leg cycling and handgrip exercise vs. Comorbidity-matched controls and healthy controls was evaluated on Relationship between change in muscle sympathetic nerve activity (MSNA) during moderate cycling and relative VO2peak (r = -0.72, p=<0.01). In patients with HFpEF, the paradoxical increase in muscle sympathetic nerve activity during moderate cycling related inversely to relative peak oxygen uptake (r=-0.72; P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: