Key result
Dynamic one-legged exercise increased muscle sympathetic nerve activity burst frequency in patients with HFrEF (+6.9 bursts/min) but decreased it in healthy controls (-5.5 bursts/min; P<0.001).
Why the study?
Does dynamic one-legged exercise alter muscle sympathetic nerve activity in HFrEF patients compared to healthy controls?
Population
29 subjects: 16 patients with HFrEF and 13 healthy control subjects.
Comparison
2 min of upright one-legged unloaded cycling… vs Age- and sex-matched healthy controls undergoing…
Design
Cross-sectional
Authors
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May limit exercise capacity in HFrEF; hypothesis-generating and leaves open causal role or therapeutic targeting.
Observational (n=29)
Does dynamic one-legged exercise alter muscle sympathetic nerve activity in HFrEF patients compared to healthy controls?
Absolute Event Rate: 6.9% vs -5.5%
p-value: p=<0.001
Dynamic leg exercise elicits sympathoexcitation in HFrEF patients but a decrease in healthy subjects, which correlates inversely with exercise capacity and may explain limited functional capacity in heart failure.
Notarius et al. (2014) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=29). Dynamic one-legged exercise vs. Healthy age- and sex-matched controls was evaluated on Change in muscle sympathetic nerve activity (MSNA) burst frequency during mild to moderate dynamic exercise (p=<0.001). Dynamic one-legged exercise increased muscle sympathetic nerve activity burst frequency in patients with HFrEF (+6.9 bursts/min) but decreased it in healthy controls (-5.5 bursts/min; P<0.001).
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