Female sex was not associated with the risk of all-cause mortality compared to male sex in patients with HFmrEF at 30 months (HR 0.931; 95% CI 0.797-1.088; P=0.372).
Cohort (n=2,184)
No
Does sex impact all-cause mortality and HF-related rehospitalization in patients hospitalized with HFmrEF?
In patients hospitalized with HFmrEF, sex does not predict all-cause mortality, but female sex is associated with a higher risk of HF-related rehospitalization.
Effect estimate: HR 0.931 (95% CI 0.797-1.088)
p-value: p=0.372
Background The study investigates the prognostic impact of sex and sex‐related differences in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). More data regarding the characterization of patients and their outcomes in the presence of HFmrEF are needed. Methods and Results Consecutive patients hospitalized with HFmrEF (ie, left ventricular ejection fraction 41%–49% and signs or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Female patients were compared with male patients with regard to the primary end point of all‐cause mortality at 30 months (median follow‐up). Statistical analyses comprised Kaplan–Meier, multivariable Cox proportional regression analyses and propensity score matching. From a total of 2184 patients hospitalized with HFmrEF, 64.6% were male. Female patients with HFmrEF were older than male patients (median age 78 versus 73 years; P =0.001) and had lower rates of ischemic cardiomyopathy (46.6% versus 63.6%; P =0.001). Within the entire study cohort, sex was not associated with the risk of all‐cause mortality (hazard ratio HR, 0.931 95% CI, 0.797–1.088; P =0.372). However, male sex was associated with a lower risk of HF‐related rehospitalization at 30 months (HR, 0.761 95% CI, 0.600–0.966; P =0.026), which was confirmed after multivariable adjustment (HR, 0.759 95% CI, 0.592–0.973; P =0.029) and propensity score matching (HR, 0.722 95% CI, 0.539–0.967; P =0.029). Conclusion Although almost two thirds of patients hospitalized with HFmrEF were male, sex was no predictor for the risk of all‐cause mortality at 30 months. However, female sex was associated with a higher risk of HF‐related rehospitalization. Registration URL: https://clinicaltrials.gov; Unique identifier: NCT05603390.
Reinhardt et al. (Thu,) conducted a cohort in Heart failure with mildly reduced ejection fraction (HFmrEF) (n=2,184). Female sex vs. Male sex was evaluated on All-cause mortality (HR 0.931, 95% CI 0.797-1.088, p=0.372). Female sex was not associated with the risk of all-cause mortality compared to male sex in patients with HFmrEF at 30 months (HR 0.931; 95% CI 0.797-1.088; P=0.372).