Endothelial dysfunction in AMI patients was significantly associated with poor sleep quality (p=0.001), lower sleep efficiency (p=0.016), and reduced cardiorespiratory fitness (p=0.017).
Observational (n=63)
Is endothelial dysfunction associated with poor sleep quality, reduced cardiorespiratory fitness, and adverse outcomes in patients with acute myocardial infarction treated with primary PCI?
Endothelial dysfunction in post-AMI patients is significantly associated with poor sleep quality, reduced cardiorespiratory fitness, and potentially higher risk of short-term major adverse cardiac events.
p-value: p=0.001
BACKGROUND: Endothelial function (EndFx) is a core component of cardiovascular (CV) health and cardioprotection following acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI). HYPOTHESIS: AMI patients experience endothelial dysfunction (EndDys), associated with traditional CV risk factors and sleep patterns. EndFx may also predict short and mid-term outcomes. METHODS: EndFx was assessed in 63 patients (56.2 ± 7.6 years) using the Endothelium Quality Index (EQI). Sleep quality and quantity were evaluated using objective (actigraphy) and subjective (Pittsburgh Sleep Quality Index questionnaire) measures. Cardiorespiratory fitness was quantified through the 6-min walking test. Cardiac function was assessed using the left ventricular ejection fraction. RESULTS: adjusted = 0.50, p < 0.001). Patients with EndDys had poor sleep quality (p = 0.001) and sleep efficiency (p = 0.016) compared to healthy persons. Patients with severe EndDys exhibited lower cardiorespiratory fitness compared to those with healthy EndFx (p = 0.017). Furthermore, during a follow-up period (nearly 4 months) following PCI, major adverse cardiac events were observed in four patients with severe EndDys. CONCLUSIONS: Our results emphasize the importance of adequate sleep and an active lifestyle, notably physical activity practice, as modifiable elements to enhance EndFx, which is regarded as a predictive tool following AMI. However, other factors remain to be elucidated as predictors of CV risk. TRIAL REGISTRATION: The study protocol was registered in the Pan African Clinical Trial Registry under the trial ID: PACTR202208834230748.
Hbaieb et al. (Wed,) conducted a observational in Acute Myocardial Infarction (n=63). Endothelial dysfunction vs. Healthy endothelial function / healthy persons was evaluated on Sleep quality, sleep efficiency, and cardiorespiratory fitness (p=0.001). Endothelial dysfunction in AMI patients was significantly associated with poor sleep quality (p=0.001), lower sleep efficiency (p=0.016), and reduced cardiorespiratory fitness (p=0.017).