From 1999 to 2020, the age-adjusted mortality rate for atherosclerotic heart disease declined from 291.08 to 170.07 per 100,000 persons (AAPC -2.70%), with an abrupt rise from 2018 to 2020.
Observational (n=7,638,608)
While atherosclerotic heart disease mortality in the U.S. declined significantly from 1999 to 2020, an alarming reversal occurred between 2018 and 2020, with persistent gender and racial disparities.
Effect estimate: AAPC -2.70% (95% CI 2.96 to -2.54)
Absolute Event Rate: 170.07% vs 291.08%
Background: Atherosclerotic heart disease (ASHD) remains a leading cause of mortality worldwide, especially among older adults. Understanding the long-term mortality trends in ASHD can guide public health strategies and address demographic disparities. Methods: Mortality data for individuals aged 35 years and older were extracted from the CDC WONDER database. Age-adjusted mortality rates (AAMR) per 100,000 persons were calculated and stratified by year, gender, race, urbanization, and place of death. The trends were assessed using the annual percent change (APC) and average annual percent change (AAPC) with 95 % confidence intervals (CI) calculated through Joinpoint regression analysis. Results: From 1999 to 2020, 7,638,608 ASHD-related deaths were recorded. The overall AAMR declined from 291.08 in 1999 to 170.07 in 2020, with an AAPC of -2.70 % (95 % CI: 2.96 to -2.54). However, an abrupt rise was observed from 2018 to 2020 (APC: 4.55; 95 % CI: 0.77 to 6.75). Males reported higher AAMR than females (Males: 271.9 vs. Females: 151.9). Non-Hispanic (NH) White individuals had the highest AAMR (209.38), followed by NH Black (202.47), NH American Indian (176.12), Hispanic (158.1), and NH Asian (113.7) populations. Nonmetropolitan areas reported the highest AAMR (214.77), while medium metropolitan areas reported the lowest (195.41). The majority of deaths occurred in medical facilities (42.81 %), followed by decedent's homes (25.67 %), and nursing homes (24.79 %). Conclusion: Despite a long-term decline in ASHD-related mortality, the recent increase from 2018 to 2020 requires further study. Gender and racial disparities persist, highlighting the need for targeted public health efforts to reduce these inequities.
Akhtar et al. (Mon,) conducted a observational in Atherosclerotic heart disease (n=7,638,608). Time period (1999-2020) was evaluated on Age-adjusted mortality rate (AAMR) per 100,000 persons (AAPC -2.70%, 95% CI 2.96 to -2.54). From 1999 to 2020, the age-adjusted mortality rate for atherosclerotic heart disease declined from 291.08 to 170.07 per 100,000 persons (AAPC -2.70%), with an abrupt rise from 2018 to 2020.