A total risk score integrating multiple cardiovascular risk factors was linearly associated with new-onset diabetes after AMI, with a 1.2-fold risk increase per 1-point rise (95% CI 1.191-1.276).
Cohort (n=5,147)
Post-AMI patients, particularly those who are middle-aged, of Arab ethnicity, or have metabolic syndrome or HbA1c ≥ 6%, have a high long-term risk of developing new-onset type 2 diabetes.
Effect estimate: 1.2-fold rise per 1-point increase (95% CI 1.191-1.276)
p-value: p=<0.001
Acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM) share common risk factors. To evaluate the long-term incidence and predictors of new-onset T2DM (NODM) among post-AMI adults, we conducted a retrospective analysis of AMI survivors hospitalized between 2002 and 2017. Eligible patients were followed for up to 16 years to identify NODM, stratified by demographic and clinical characteristics. Among 5147 individuals (74.2% males, mean age 64.6 ± 14.9 years) without pre-existing T2DM, 23.4% developed NODM (cumulative incidence: 0.541). Key risk factors included an age of 50–60 years, a minority ethnicity (Arabs), smoking, metabolic syndrome (MetS), hemoglobin A1C (HbA1C) ≥ 5.7%, and cardiovascular comorbidities. A total score (TS), integrating these factors, revealed a linear association with the NODM risk: each 1-point increase corresponded to a 1.2-fold rise (95% CI 1.191–1.276, p < 0.001). HbA1C ≥ 6% on the “Pre-DM sub-scale” conferred a 2.8-fold risk (p < 0.001), while other risk factors also independently predicted NODM. In conclusion, post-AMI patients with multiple cardiovascular risk factors, particularly middle-aged individuals, Arab individuals, and those with HbA1C ≥ 6% or MetS, are at a heightened risk of NODM. Early identification and targeted interventions may mitigate this risk.
Yakubov et al. (Fri,) conducted a cohort in Acute myocardial infarction (AMI) (n=5,147). Total score (TS) integrating cardiovascular risk factors vs. Lower total score was evaluated on New-onset type 2 diabetes mellitus (NODM) (1.2-fold rise per 1-point increase, 95% CI 1.191-1.276, p=<0.001). A total risk score integrating multiple cardiovascular risk factors was linearly associated with new-onset diabetes after AMI, with a 1.2-fold risk increase per 1-point rise (95% CI 1.191-1.276).